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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SH2B1 All Species: 13.64
Human Site: S435 Identified Species: 42.86
UniProt: Q9NRF2 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NRF2 NP_001139267.1 756 79336 S435 S E S N D R L S Q G A Y G G L
Chimpanzee Pan troglodytes XP_001138906 438 45860 Q170 H S E S L P S Q D L L L G P S
Rhesus Macaque Macaca mulatta XP_001096611 747 78691 S426 S E S N D R L S Q G A Y G G L
Dog Lupus familis XP_849871 671 70893 N403 T S F L T R E N T D S L E L P
Cat Felis silvestris
Mouse Mus musculus Q91ZM2 756 79606 S435 S E S N D R L S Q G A Y G G L
Rat Rattus norvegicus Q62985 756 79618 S435 S E S N D R L S Q G A Y G G L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001103925 906 96945 A601 R D A V Q M R A W L S D I R N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624395 579 64607 N311 T V Q Q N S I N P N S G I E A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 56.8 95.9 83 N.A. 91.8 91.2 N.A. N.A. N.A. N.A. 33.1 N.A. N.A. 28.8 N.A. N.A.
Protein Similarity: 100 57 96.8 84.5 N.A. 93.5 93.6 N.A. N.A. N.A. N.A. 45 N.A. N.A. 40.7 N.A. N.A.
P-Site Identity: 100 6.6 100 6.6 N.A. 100 100 N.A. N.A. N.A. N.A. 0 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 100 13.3 100 26.6 N.A. 100 100 N.A. N.A. N.A. N.A. 26.6 N.A. N.A. 33.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 13 0 0 0 0 13 0 0 50 0 0 0 13 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 13 0 0 50 0 0 0 13 13 0 13 0 0 0 % D
% Glu: 0 50 13 0 0 0 13 0 0 0 0 0 13 13 0 % E
% Phe: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 50 0 13 63 50 0 % G
% His: 13 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 13 0 0 0 0 0 25 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 13 13 0 50 0 0 25 13 25 0 13 50 % L
% Met: 0 0 0 0 0 13 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 50 13 0 0 25 0 13 0 0 0 0 13 % N
% Pro: 0 0 0 0 0 13 0 0 13 0 0 0 0 13 13 % P
% Gln: 0 0 13 13 13 0 0 13 50 0 0 0 0 0 0 % Q
% Arg: 13 0 0 0 0 63 13 0 0 0 0 0 0 13 0 % R
% Ser: 50 25 50 13 0 13 13 50 0 0 38 0 0 0 13 % S
% Thr: 25 0 0 0 13 0 0 0 13 0 0 0 0 0 0 % T
% Val: 0 13 0 13 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 50 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _